rs1553385404

A SNP. Its most notable genotype is -;G: Hypercholesterolemia, Type B; heterozygote

Gene
None listed
Highest magnitude
3.1Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;GMost notableBadHypercholesterolemia, Type B; heterozygoteImportant · 3.1

On SNPedia: (-;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.2786dupC (p.Arg931fs) and also c.2786delC (p.Pro929fs); in ClinVar, the former is reported as pathogenic for (dominant) familial hypercholesterolemia, and the latter as pathogenic for (recessive) familial hypobetalipoproteinemia

-;G

Check cholesterol levels; if high, increased risk of cardiovascular disease. Note: if raw data is "DI", exact mutation may be ambiguous.

Source and license

Adapted from rs1553385404 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.