rs1554483

A SNP in the CLOCK gene on chromosome 4. Its most notable genotype is C;C: normal

Gene
CLOCK
Location
Chr 455,455,650 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.037% of people
  2. C;GNot rated1.8x higher risk for obesity if in haplotypeTypical · 0.038% of people
  3. G;GNot rated1.8x higher risk for obesity if in haplotypeTypical · 0.025% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 37% C;G 38% G;G 25%
  • European ancestry (Utah)C;C 48% C;G 37% G;G 15%
  • Han Chinese (Beijing)C;C 16% C;G 39% G;G 46%
  • Japanese (Tokyo)C;C 13% C;G 49% G;G 38%
  • Yoruba (Nigeria)C;C 70% C;G 27% G;G 3%

Conditions, medicines and genes

Other CLOCK SNPs

All CLOCK SNPs

Notes

From SNPedia

Notes

A study of 391 overweight patients concluded that the haplotype of rs1554483(G) and rs4864548(A) was associated with a 1.8-fold higher risk (CI: 1.31-2.54, p < 0.001) of obesity.

Source and license

Adapted from rs1554483 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.