rs4864548

A SNP in the CLOCK gene on chromosome 4. Its most notable genotype is A;A: normal

Gene
CLOCK
Location
Chr 455,547,636 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.017% of people
  2. A;GNot rated1.8x higher risk for obesity if in haplotypeTypical · 0.042% of people
  3. G;GNot rated1.8x higher risk for obesity if in haplotypeTypical · 0.042% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 17% A;G 42% G;G 42%
  • European ancestry (Utah)A;A 13% A;G 50% G;G 37%
  • Han Chinese (Beijing)A;A 38% A;G 45% G;G 17%
  • Japanese (Tokyo)A;A 33% A;G 52% G;G 15%
  • Yoruba (Nigeria)A;A 3% A;G 29% G;G 69%
  • African ancestry (Southwest US)A;A 0% A;G 40% G;G 60%
  • Chinese (Denver)A;A 41% A;G 44% G;G 15%
  • Gujarati IndianA;A 18% A;G 52% G;G 31%
  • Luhya (Kenya)A;A 2% A;G 21% G;G 77%
  • Mexican ancestry (Los Angeles)A;A 19% A;G 43% G;G 38%
  • Maasai (Kenya)A;A 3% A;G 38% G;G 60%
  • TuscanA;A 13% A;G 45% G;G 42%

Conditions, medicines and genes

Other CLOCK SNPs

All CLOCK SNPs

Notes

From SNPedia

Notes

A study of 391 overweight patients concluded that the haplotype of rs1554483(G) and rs4864548(A) was associated with a 1.8-fold higher risk (CI: 1.31-2.54, p < 0.001) of obesity.

Source and license

Adapted from rs4864548 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.