rs1555344723

A SNP. Its most notable genotype is C;T: Marsili syndrome (predicted); pain insensitivity

Gene
None listed
Highest magnitude
6.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableNot ratedMarsili syndrome (predicted); pain insensitivityVery important · 6.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.5738G>A (p.Arg1913Lys) This mutation in the ZFHX2 gene was reported in 2018 in an Italian family (the Marsili's) exhibiting inherited pain insensitivity. The mutation is inherited as an autosomal dominant, and the associated syndrome is currently called Marsili syndrome. See also OMIM 617828.0001

C;T

see text and links via main rs-page

Source and license

Adapted from rs1555344723 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.