rs1571801
A SNP in the DAB2IP gene on chromosome 9. Its most notable genotype is T;T: >1.36x risk for prostate cancer
- Gene
- DAB2IP
- Location
- Chr 9121,665,094 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 17%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBad>1.36x risk for prostate cancer
- G;TNot rated1.36x risk for prostate cancer
- G;GNot ratedaverage
- C;CNot ratedNo summary available.
SNPedia records rs1571801 on the minus strand: (A;A), (A;C), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 2% G;T 24% G;G 75% C;C 0%
- European ancestry (Utah)T;T 7% G;T 44% G;G 49% C;C 0%
- Han Chinese (Beijing)T;T 0% G;T 13% G;G 87% C;C 0%
- Japanese (Tokyo)T;T 0% G;T 7% G;G 93% C;C 0%
- Yoruba (Nigeria)T;T 1% G;T 26% G;G 73% C;C 0%
- African ancestry (Southwest US)T;T 4% G;T 32% G;G 64% C;C 0%
- Chinese (Denver)T;T 0% G;T 9% G;G 91% C;C 0%
- Gujarati IndianT;T 3% G;T 19% G;G 78% C;C 0%
- Luhya (Kenya)T;T 0% G;T 24% G;G 76% C;C 0%
- Mexican ancestry (Los Angeles)T;T 2% G;T 28% G;G 70% C;C 0%
- Maasai (Kenya)T;T 2% G;T 29% G;G 69% C;C 0%
- TuscanT;T 3% G;T 27% G;G 70% C;C 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 200 words
In a study of ~1000 Caucasian patients with prostate cancer, rs1571801 was the SNP most associated with not only prostate cancer, but having an aggressive form of it. The odds ratio for aggressive prostate cancer associated with the risk allele, rs1571801(A), was 1.36 (CI: 1.13 - 1.65, p = 0.001). The odds ratio associated with (nonaggressive) prostate cancer was also higher than average for this SNP; for the same (A) risk allele, it was 1.27 (CI: 1.10 - 1.48, p = 0.0017). Although the association was found in a study of Caucasian patients, it was also reported to be statistically significant in a population of 210 African-Americans with prostate cancer. According to oncology-information.com, "The odds ratio for aggressive prostate cancer ranged from 1.29 to 1.50 in men with one or two copies of the mutant A allele compared with noncarriers." rs1571801 is located in the DAB2IP gene and encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor. Associated with aggressive prostate cancer in a study of prostate cancer patients of European descent. Also statistically significant in an African American study population.
Source and license
Adapted from rs1571801 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.