rs1585215

A SNP in the NFKB1 gene on chromosome 4. Its most notable genotype is C;C: 3.5x increased risk for Hodgkin lymphoma

Gene
NFKB1
Location
Chr 4102,523,317 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodnormalTypical · 0.049% of people
  2. C;TBad2x increased risk for Hodgkin lymphomaWorth knowing · 2.044% of people
  3. C;CMost notableBad3.5x increased risk for Hodgkin lymphomaWorth knowing · 2.17% of people

SNPedia records rs1585215 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 49% C;T 44% C;C 7%
  • European ancestry (Utah)T;T 34% C;T 57% C;C 9%
  • Han Chinese (Beijing)T;T 29% C;T 67% C;C 4%
  • Japanese (Tokyo)T;T 36% C;T 49% C;C 16%
  • Yoruba (Nigeria)T;T 98% C;T 2% C;C 0%

Conditions, medicines and genes

Other NFKB1 SNPs

All NFKB1 SNPs

Notes

From SNPedia

Notes

rs1585215 is a SNP in the NFKB1 gene. A population-based case-control study including 473 cases of Hodgkin lymphoma concluded that increased risk for the disease was significantly associated with rs1585215. The odds ratio for rs1585215(G;G) homozygotes was 3.5 (CI: 2.2-5.7, Ptrend = 1.7 x 10(-8)), and for (A;G) heterozygotes, 2.1 (CI: 1.5-2.9).

Source and license

Adapted from rs1585215 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.