rs4648022

A SNP in the NFKB1 gene on chromosome 4. Its most notable genotype is T;T: 0.47x reduced risk for NHL

Gene
NFKB1
Location
Chr 4102,575,280 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadNormal risk for NHL. The minor, protective allele is rare.Typical · 0.093% of people
  2. C;TGood0.58x reduced risk of NHLMinor · 1.27% of people
  3. T;TMost notableGood0.47x reduced risk for NHLMinor · 1.4<1% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageC;C 93% C;T 7% T;T <1%
  • European ancestry (Utah)C;C 83% C;T 17% T;T 0%
  • Han Chinese (Beijing)C;C 100% C;T 0% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • African ancestry (Southwest US)C;C 97% C;T 4% T;T 0%
  • Gujarati IndianC;C 90% C;T 10% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 95% C;T 5% T;T 0%
  • Maasai (Kenya)C;C 94% C;T 6% T;T 0%
  • TuscanC;C 80% C;T 18% T;T 2%

Other NFKB1 SNPs

All NFKB1 SNPs

Notes

From SNPedia

Notes

Non-Hodgkin's lymphoma rs4648022) was associated with NHL risk overall (ordinal OR, 0.59; 95% CI, 0.41-0.84; P(trend) = 0.0037)

C;T

The rare minor T allele is protective for NHL in general and subtypes, with a reduction in risk of 0.58x (95% CI .40-.84) p-trend=.0037. Risk reduction is likely greater in very rare TT homozygotes.

T;T

The rare minor T allele is protective for NHL in general and subtypes, with a reduction in risk of 0.47x (95% CI .04-5.24) p-trend=.0037. Risk reduction is likely greater in very rare TT homozygotes, but the CI is large due to the rarity of this genotype, and the p-trend includes the risk reduction in the more common heterozygotes.

Source and license

Adapted from rs4648022 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.