rs4648022(T;T)

0.47x reduced risk for NHL

Magnitude
1.4Minor
Repute
Good
Frequency
<1%Average of 9 populations
On SNPedia
rs4648022(T;T)
Gene
NFKB1

Frequency

Share of people with T;T in each HapMap population.

  • Tuscan2%
  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Gujarati Indian0%
  • Mexican ancestry (Los Angeles)0%
  • Maasai (Kenya)0%

Other genotypes of rs4648022

  1. C;CBadNormal risk for NHL. The minor, protective allele is rare.Typical · 0.093% of people
  2. C;TGood0.58x reduced risk of NHLMinor · 1.27% of people

All about rs4648022

Notes

From SNPedia

The rare minor T allele is protective for NHL in general and subtypes, with a reduction in risk of 0.47x (95% CI .04-5.24) p-trend=.0037. Risk reduction is likely greater in very rare TT homozygotes, but the CI is large due to the rarity of this genotype, and the p-trend includes the risk reduction in the more common heterozygotes.

Source and license

Adapted from rs4648022(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.