rs17070145

A SNP in the WWC1 gene on chromosome 5. Its most notable genotype is C;C: reduced memory abilities

Gene
WWC1
Location
Chr 5168,418,786 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadreduced memory abilitiesWorth knowing · 2.123% of people
  2. C;TGoodincreased memory performanceWorth knowing · 2.042% of people
  3. T;TGoodgreatly increased memory performanceWorth knowing · 2.134% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 23% C;T 42% T;T 34%
  • European ancestry (Utah)C;C 47% C;T 43% T;T 11%
  • Han Chinese (Beijing)C;C 7% C;T 38% T;T 56%
  • Japanese (Tokyo)C;C 2% C;T 30% T;T 68%
  • Yoruba (Nigeria)C;C 11% C;T 46% T;T 44%
  • African ancestry (Southwest US)C;C 18% C;T 54% T;T 28%
  • Chinese (Denver)C;C 4% C;T 38% T;T 59%
  • Gujarati IndianC;C 54% C;T 38% T;T 9%
  • Luhya (Kenya)C;C 24% C;T 43% T;T 34%
  • Mexican ancestry (Los Angeles)C;C 16% C;T 53% T;T 31%
  • Maasai (Kenya)C;C 30% C;T 44% T;T 26%
  • TuscanC;C 45% C;T 41% T;T 14%

Other WWC1 SNPs

All WWC1 SNPs

Notes

From SNPedia

Show notes, about 290 words

In a Swiss cohort: "Carriers of KIBRA rs17070145 T allele had 24% better free recall performance 5 min after word presentation (P = 0.000004) and 19% better free recall performance 24 hours after word presentation (P = 0.0008) than did noncarriers." In a US cohort: "T allele carriers had significantly better memory scores than non-carriers in the Buschke's Selective Reminding Test (SRT). Performance on another episodic memory task, the Rey Auditory Verbal Learning Test (AVLT), was also significantly different between allele groups." In another Swiss cohort, with a visual episodic memory task: "T allele carriers also performed significantly better than did noncarriers in this population." "Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval." Replication in a healthy elderly cohort. Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment. Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. Evidence for an association between KIBRA and late-onset Alzheimer's disease. Association of KIBRA and memory. Caspase-1 genetic variation is not associated with Alzheimer's disease risk. KIBRA: A New Gateway to Learning and Memory? Impact of common KIBRA allele on human cognitive functions. The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.

T;T

Greatly improved memory performance

Source and license

Adapted from rs17070145 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.