rs749318706

A SNP in the WWC1 gene on chromosome 5. Its most notable genotype is C;T: De novo mutation seen in a Tourette syndrome proband; implied but unproven association

Gene
WWC1
Location
Chr 5168,467,849 (GRCh38)
Highest magnitude
3.0Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableBadDe novo mutation seen in a Tourette syndrome proband; implied but unproven associationImportant · 3.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other WWC1 SNPs

All WWC1 SNPs

Notes

From SNPedia

Notes

rs749318706 is a rare C>T mutation in the WWC1 gene on chromosome 1 which changes an Arg to a Stop codon. Although not implicated in any direct way as leading to Tourette syndrome, the rs749318706(T) "stop-gain" mutation is one of two mutations listed in the WWC1 gene in a 2017 publication reporting that de novo likely gene-disrupting (LGD) variants in perhaps 400+ genes are associated with Tourette syndrome. This analysis also reported that of all the genes found to contain such variants, the gene most confidently associated with recurring de novo variants was the WWC1 gene.

C;T

see discussion at rs749318706

Source and license

Adapted from rs749318706 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.