rs172149856
A SNP in the TRPM4 gene on chromosome 19. Its most notable genotype is A;G: May - or may not - lead to progressive familial heart block type 1B
- Gene
- TRPM4
- Location
- Chr 1949,188,641 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableNot ratedMay - or may not - lead to progressive familial heart block type 1B
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TRPM4 SNPs
- rs172151858A;GProgressive familial heart block type 1B (Brugada syndrome)Very important
- rs200038418A;GProgressive familial heart block type 1B (Brugada syndrome)Very important
- rs201907325A;GProgressive familial heart block type 1B (Brugada syndrome)Very important
- rs267607142A;GProgressive familial heart block type 1B (Brugada syndrome)Very important
- rs387907216C;TProgressive familial heart block type 1B (Brugada syndrome)Very important
Notes
From SNPedia
Notes
rs172149856, also known as c.1744G>A, p.Gly582Ser and G582S, represents a rare variant in the TRPM4 gene on chromosome 19. The minor allele for this SNP may be associated with progressive familial heart block type 1B, but it is tagged in ClinVar as of "uncertain significance". An additional mention is found in OMIM 606936.0005.
A;G
see discussion at rs172149856
Source and license
Adapted from rs172149856 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.