rs173686

A SNP in the VCAN gene on chromosome 5. Its most notable genotype is C;T.

Gene
VCAN
Location
Chr 583,515,681 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. A;ANot ratedNo summary available.Typical · 0.012% of people

SNPedia records rs173686 on the minus strand: (A;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 0% A;A 12%
  • European ancestry (Utah)C;T 0% A;A 37%
  • Han Chinese (Beijing)C;T 0% A;A 2%
  • Japanese (Tokyo)C;T 0% A;A 0%
  • Yoruba (Nigeria)C;T 0% A;A 3%
  • African ancestry (Southwest US)C;T 0% A;A 4%
  • Chinese (Denver)C;T 0% A;A 2%
  • Gujarati IndianC;T 0% A;A 32%
  • Luhya (Kenya)C;T 0% A;A <1%
  • Mexican ancestry (Los Angeles)C;T 0% A;A 26%
  • Maasai (Kenya)C;T 0% A;A 4%
  • TuscanC;T 0% A;A 27%

Conditions, medicines and genes

Other VCAN SNPs

All VCAN SNPs

Notes

From SNPedia

Notes

The presence of an rs173686(C) allele has been linked to increased risk of a certain type of stroke, Intracranial Aneurysm, in a population of Dutch adults. A study of 240 Chinese Han nationality patients with at least one intracranial aneurysm and matched controls did not replicate this result. Note: the dbSNP sequence entry for this SNP represents the noncoding strand, and is thus the reverse complement compared to the SNP as referred to in .

Source and license

Adapted from rs173686 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.