rs251124

A SNP in the VCAN gene on chromosome 5. Its most notable genotype is T;T.

Gene
VCAN
Location
Chr 583,509,605 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedNo summary available.Typical · 0.17% of people

On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 7%
  • European ancestry (Utah)T;T <1%
  • Han Chinese (Beijing)T;T 13%
  • Japanese (Tokyo)T;T 10%
  • Yoruba (Nigeria)T;T 3%
  • African ancestry (Southwest US)T;T 9%
  • Chinese (Denver)T;T 18%
  • Gujarati IndianT;T 6%
  • Luhya (Kenya)T;T 4%
  • Mexican ancestry (Los Angeles)T;T 2%
  • Maasai (Kenya)T;T 6%
  • TuscanT;T 4%

Other VCAN SNPs

All VCAN SNPs

Notes

From SNPedia

Notes

failed to reproduce evidence of intracranial aneurysms in a Han Chinese population journal rs251124 (OR=1.43,95% CI=1.09 to 1.88, P=0.008) disruption of the extracellular matrix (ECM) of the arterial wall and is a likely factor in the pathogenesis of intracranial aneurysms (IAs).

T;T

Only published in a small caucasian population, then failed to reproduce in a chinese population

Source and license

Adapted from rs251124 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.