rs17482078

A SNP in the ERAP1 gene on chromosome 5. Its most notable genotype is C;C: 0.76x lower risk for spondylitis

Gene
ERAP1
Location
Chr 596,783,162 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated0.76x lower risk for spondylitisTypical · 0.082% of people
  2. C;TGood0.76x lower risk for spondylitisTypical · 0.016% of people
  3. T;TNot ratednormal riskTypical · 0.01% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 82% C;T 16% T;T 1%
  • European ancestry (Utah)C;C 58% C;T 35% T;T 7%
  • Han Chinese (Beijing)C;C 86% C;T 14% T;T 0%
  • Japanese (Tokyo)C;C 84% C;T 16% T;T 0%
  • Yoruba (Nigeria)C;C 88% C;T 10% T;T 2%
  • African ancestry (Southwest US)C;C 84% C;T 14% T;T 2%
  • Chinese (Denver)C;C 90% C;T 10% T;T 0%
  • Gujarati IndianC;C 89% C;T 11% T;T 0%
  • Luhya (Kenya)C;C 89% C;T 10% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 82% C;T 18% T;T 0%
  • Maasai (Kenya)C;C 92% C;T 7% T;T <1%
  • TuscanC;C 65% C;T 33% T;T 2%

Conditions, medicines and genes

Other ERAP1 SNPs

All ERAP1 SNPs

Notes

From SNPedia

Notes

rs17482078 is one of several SNPs in the ERAP1 gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.70 (p=1.2x10e-8).PMID 17952073, PMID 18037607

Source and license

Adapted from rs17482078 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.