rs2549782
A SNP in the ERAP1 gene on chromosome 5. Its most notable genotype is G;G: 1.6x increased risk for preeclampsia in most populations
- Gene
- ERAP1
- Location
- Chr 596,895,296 (GRCh38)
- Highest magnitude
- 1.6Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 45%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableBad1.6x increased risk for preeclampsia in most populations
- G;TBad1.3x increased risk for preeclampsia in most populations
- T;TNot ratedNo summary available.
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 20% G;T 50% T;T 31%
- European ancestry (Utah)G;G 24% G;T 48% T;T 28%
- Han Chinese (Beijing)G;G 14% G;T 47% T;T 38%
- Japanese (Tokyo)G;G 19% G;T 56% T;T 25%
- Yoruba (Nigeria)G;G 16% G;T 44% T;T 40%
- African ancestry (Southwest US)G;G 14% G;T 46% T;T 40%
- Chinese (Denver)G;G 12% G;T 58% T;T 30%
- Gujarati IndianG;G 18% G;T 50% T;T 32%
- Luhya (Kenya)G;G 26% G;T 59% T;T 16%
- Mexican ancestry (Los Angeles)G;G 21% G;T 43% T;T 36%
- Maasai (Kenya)G;G 33% G;T 49% T;T 18%
- TuscanG;G 20% G;T 47% T;T 34%
Related
Conditions, medicines and genes
Other ERAP1 SNPs
- rs30187T;T2x higher risk for Ankylosing Spondylitis.Worth knowing
- rs10050860T;THalf the risk (about 0.05%) of Ankylosing Spondylitis.Minor
- rs27044C;Cnormal riskTypical
- rs2287987C;C0.71x lower risk for spondylitisTypical
- rs3734016C;Ccommon on affy axiom dataTypical
- rs17408150T;Tcommon on affy axiom dataTypical
- rs17482078C;C0.76x lower risk for spondylitisTypical
Notes
From SNPedia
Notes
rs2549782 is a SNP in the endoplasmic reticulum aminopeptidase 2 ERAP2 gene. A case-control study of 1103 Chilean maternal-fetal dyads and 1637 unpaired African American samples (836 maternal, 837 fetal) concluded that the fetal minor allele rs2549782(G) was associated with 1.3x increased risk (CI: 1.075-1.619) for pre-eclampsia in the African American population (p = 0.009), but not in the Chilean population. }}
G;G
Note: this is relevant to the fetal genotype, not the maternal genotype
G;T
Note that this is relevant to the fetal genotype, not the maternal genotype
Source and license
Adapted from rs2549782 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.