rs1799722

A SNP in the BDKRB2 gene on chromosome 14. Its most notable genotype is T;T: Associated with endurance performance

Gene
BDKRB2
Location
Chr 1496,204,802 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodAssociated with endurance performanceMinor · 1.017% of people

On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 17%
  • European ancestry (Utah)T;T 20%
  • Han Chinese (Beijing)T;T 33%
  • Japanese (Tokyo)T;T 27%
  • Yoruba (Nigeria)T;T 3%
  • African ancestry (Southwest US)T;T 14%
  • Chinese (Denver)T;T 28%
  • Gujarati IndianT;T 15%
  • Luhya (Kenya)T;T 4%
  • Mexican ancestry (Los Angeles)T;T 14%
  • Maasai (Kenya)T;T 7%
  • TuscanT;T 27%

Other BDKRB2 SNPs

All BDKRB2 SNPs

Notes

From SNPedia

Notes

T;T

In Mount Olympus marathon runners, male athletes showed a statistically significant yet slight excess of the TT genotype at rs1799722 (bradykinin B2 receptor, BDKRB2) (P=0.018; P=0.006 when limited to 316 habitual male runners) Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. Bradykinin dilates blood vessels by stimulating the release of prostacyclin and nitric oxide (NO). Bradykinin levels are increased by ACE inhibitors.

References

Source and license

Adapted from rs1799722 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.