rs1799883

A SNP in the FABP2 gene on chromosome 4. Its most notable genotype is T;T: Two copies of the Thr allele in the FABP2 is associated with significantly increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.

Gene
FABP2
Location
Chr 4119,320,747 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
25%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodTwo copies of the Thr allele in the FABP2 is associated with significantly increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.Typical · 0.08% of people
  2. C;TNot ratedA single copy of the Thr allele associated with a moderately increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity.Typical · 0.039% of people
  3. C;CNot ratedThis genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.Typical · 0.053% of people

SNPedia records rs1799883 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 8% C;T 39% C;C 53%
  • European ancestry (Utah)T;T 7% C;T 51% C;C 42%
  • Han Chinese (Beijing)T;T 8% C;T 47% C;C 45%
  • Japanese (Tokyo)T;T 10% C;T 48% C;C 42%
  • Yoruba (Nigeria)T;T 8% C;T 38% C;C 54%
  • African ancestry (Southwest US)T;T 2% C;T 40% C;C 58%
  • Chinese (Denver)T;T 6% C;T 33% C;C 61%
  • Gujarati IndianT;T 16% C;T 45% C;C 39%
  • Luhya (Kenya)T;T 7% C;T 25% C;C 69%
  • Mexican ancestry (Los Angeles)T;T 14% C;T 37% C;C 49%
  • Maasai (Kenya)T;T 3% C;T 32% C;C 65%
  • TuscanT;T 6% C;T 37% C;C 57%

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 170 words

rs1799883 Fatty acid binding protein 2 (FABP2) Ala54Thr; The derived allele at SNP (A54T), rs1799883, in FABP2 increases strongly with latitude (p < 0.01) and may influence weight management Identification of four gene variants associated with myocardial infarction. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Development of a fingerprinting panel using medically relevant polymorphisms. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

Source and license

Adapted from rs1799883 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.