rs1799990(A;A)

Increased chance of Prion Disease (PrP 129 Met homozygote)

Magnitude
2.3Worth knowing
Repute
Bad
Frequency
58%Average of 11 populations
On SNPedia
rs1799990(A;A)
Gene
PRNP

Frequency

Share of people with A;A in each HapMap population.

  • Chinese (Denver)98%
  • Japanese (Tokyo)97%
  • Han Chinese (Beijing)93%
  • Gujarati Indian58%
  • Maasai (Kenya)50%
  • Yoruba (Nigeria)48%
  • European ancestry (Utah)44%
  • Luhya (Kenya)43%
  • Tuscan42%
  • African ancestry (Southwest US)35%
  • Mexican ancestry (Los Angeles)35%

Other genotypes of rs1799990

  1. A;GGoodResistance to vCJD (PrP 129 Met/Val heterozygote), 4.6x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian populationWorth knowing · 2.132% of people
  2. G;GGoodResistance to vCJD (PrP 129 Val homozygous), 1.7x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian populationWorth knowing · 2.09% of people

All about rs1799990

Notes

From SNPedia

This genotype encodes for a homozygous Methionine at position 129 of PRNP, the Prion Protein gene (PrP-129MM). Unlike the protective M/V heterozgotes and V homozygous, homozygosity at this residue is associated with an increased susceptibility to sporadic CJD and and confers susceptibility against vCJD. All reported cases of vCJD, (linked to ingestion of 'mad cow disease' contaminated meat) have been 129 Met homozygous

References

Source and license

Adapted from rs1799990(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.