PRNP
29 SNPs in the PRNP gene, 15 with a genotype of magnitude 2 or higher.
- Type
- Gene
- SNPs
- 29
- Notable
- 15Magnitude 2 or higher
- Well documented
- 5
- Genosets
- 0
PRNP SNPs
Every genotype, as shown in 23andMe and AncestryDNA files.
- rs74315403Very important
- rs11538758Very important
- rs28933385Very important
- rs1799990Worth knowing
- A;AIncreased chance of Prion Disease (PrP 129 Met homozygote)Bad
- A;GResistance to vCJD (PrP 129 Met/Val heterozygote), 4.6x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian populationGood
- G;GResistance to vCJD (PrP 129 Val homozygous), 1.7x reduced risk of sporadic CJD and 0.87x reduced risk for late-onset Alzheimer in a Caucasian populationGood
- rs16990018Worth knowing
- rs74315405Very important
- rs74315401Very important
- rs74315402Very important
- rs74315406Very important
- rs74315410Very important
- rs74315413Very important
- rs74315414Very important
- rs74315415Very important
- rs398122413Very important
- rs17852079Very important
No matches.
Related
Conditions and medicines
Other SNPs
No notable genotype or detailed notes
Source and license
Adapted from PRNP on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.