rs74315405
A SNP in the PRNP gene on chromosome 20. Its most notable genotype is C;T: Gerstmann–Straussler–Scheinker syndrome
- Gene
- PRNP
- Location
- Chr 204,699,813 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;TMost notableBadGerstmann–Straussler–Scheinker syndrome
- T;TGoodcommon in clinvar
On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PRNP SNPs
- rs74315401C;TGerstmann–Straussler–Scheinker syndromeVery important
- rs74315402C;TGerstmann–Straussler–Scheinker syndromeVery important
- rs74315406A;GGerstmann–Straussler–Scheinker syndromeVery important
- rs74315410G;TGerstmann–Straussler–Scheinker syndromeVery important
- rs74315413A;GGerstmann–Straussler–Scheinker syndromeVery important
- rs74315414A;CGerstmann–Straussler–Scheinker syndromeVery important
- rs74315415C;TGerstmann–Straussler–Scheinker syndromeVery important
- rs398122413C;GGerstmann–Straussler–Scheinker syndromeVery important
Notes
From SNPedia
Notes
c.593T>C (p.Phe198Ser) 23andMe calls this i5004356
C;T
see Gerstmann–Straussler–Scheinker syndrome
Source and license
Adapted from rs74315405 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.