rs74315403(A;G)

PrP D178N pathogenic mutation - leads to CJD or FFI

Magnitude
6.5Very important
Repute
Bad
On SNPedia
rs74315403(A;G)
Gene
PRNP

Other genotypes of rs74315403

  1. G;GGoodPrP codon 178 (D) - non pathogenic variantTypical · 0.0

All about rs74315403

Notes

From SNPedia

This SNP creates a D178N mutation within the Prion Protein, which leads to inherited Creutzfeldt-Jakob disease or Fatal Familial Insomnia.

Source and license

Adapted from rs74315403(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.