rs1799998

A SNP in the CYP11B2 gene on chromosome 8. Its most notable genotype is G;G: Possibly higher odds of developing hypertension

Gene
CYP11B2
Location
Chr 8142,918,184 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadPossibly higher odds of developing hypertensionWorth knowing · 2.011% of people
  2. A;AGoodcommon/normalTypical · 0.047% of people

SNPedia records rs1799998 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 11% A;A 47%
  • European ancestry (Utah)G;G 18% A;A 31%
  • Han Chinese (Beijing)G;G 4% A;A 50%
  • Japanese (Tokyo)G;G 10% A;A 40%
  • Yoruba (Nigeria)G;G 1% A;A 72%
  • African ancestry (Southwest US)G;G 0% A;A 68%
  • Chinese (Denver)G;G 14% A;A 33%
  • Gujarati IndianG;G 21% A;A 29%
  • Luhya (Kenya)G;G 2% A;A 62%
  • Mexican ancestry (Los Angeles)G;G 19% A;A 36%
  • Maasai (Kenya)G;G 5% A;A 71%
  • TuscanG;G 25% A;A 19%

Conditions, medicines and genes

Other CYP11B2 SNPs

All CYP11B2 SNPs

Notes

From SNPedia

Notes

Known as the -344C-T polymorphism in the promoter region of the CYP11B2 gene; associated with higher plasma aldosterone-to-renin (ARR) ratios. rs1799998(C;C) homozygotes are at higher odds of developing high blood pressure than those with (C;T) or (T;T) genotypes (OR 4.0; CI: 1.4-11.6; P = 0.01). see also OMIM 124080.0010

G;G

see text and links via main rs-page

Source and license

Adapted from rs1799998 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.