rs1800371

A SNP in the TP53 gene on chromosome 17. Its most notable genotype is A;G: Slight increase in breast cancer risk for pre-menopausal African women

Gene
TP53
Location
Chr 177,676,230 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon/normalTypical · 0.097% of people
  2. A;GMost notableBadSlight increase in breast cancer risk for pre-menopausal African womenMinor · 1.72% of people

SNPedia records rs1800371 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 97% A;G 2%
  • European ancestry (Utah)G;G 100% A;G 0%
  • Han Chinese (Beijing)G;G 100% A;G 0%
  • Japanese (Tokyo)G;G 100% A;G 0%
  • Yoruba (Nigeria)G;G 89% A;G 10%

Conditions, medicines and genes

Other TP53 SNPs

All TP53 SNPs

Notes

From SNPedia

Notes

In an analysis restricted to pre-menopausal women, there was a per allele odds ratio associated with breast cancer of 1.72 (CI: 1.08-2.76; p-value = 0.023) for rs1800371(T), a functional polymorphism in the TP53 gene. Although this (Pro47Ser) variant was not associated with overall breast cancer risk, it may increase risk among pre-menopausal women of African ancestry.

A;G

see discussion at rs1800371

Source and license

Adapted from rs1800371 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.