rs1800458
A SNP in the TTR gene on chromosome 18. Its most notable genotype is G;G: common in clinvar
- Gene
- TTR
- Location
- Chr 1831,592,902 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageG;G 95%
- European ancestry (Utah)G;G 81%
- Han Chinese (Beijing)G;G 100%
- Japanese (Tokyo)G;G 100%
- Yoruba (Nigeria)G;G 100%
- African ancestry (Southwest US)G;G 98%
- Gujarati IndianG;G 99%
- Mexican ancestry (Los Angeles)G;G 93%
- TuscanG;G 92%
Related
Other TTR SNPs
- rs11541790C;TTTR-related amyloidosisVery important
- rs11541796A;GTTR-related amyloidosisVery important
- rs28933979A;GTTR-related amyloidosisVery important
- rs76992529A;GTTR-related amyloidosisVery important
- rs79977247C;TTTR-related amyloidosisVery important
- rs104894664A;GTTR-related amyloidosisVery important
- rs104894665C;TTTR-related amyloidosisVery important
- rs121918068A;TTTR-related amyloidosisVery important
Notes
From SNPedia
Notes
Transthyretin: no association between serum levels or gene variants and schizophrenia. Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.
Source and license
Adapted from rs1800458 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.