rs1800584
A SNP in the TPMT gene on chromosome 6. Its most notable genotype is T;T: TPMT*4A homozygote; likely issues detoxifying certain drugs
- Gene
- TPMT
- Location
- Chr 618,130,781 (GRCh38)
- Highest magnitude
- 3.5Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadTPMT*4A homozygote; likely issues detoxifying certain drugs
- C;TBadTPMT*4A heterozygote; possible issues detoxifying certain drugs
- C;CGoodcommon in complete genomics
SNPedia records rs1800584 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in one HapMap population.
- European ancestry (Utah)T;T 2% C;T 98% C;C 0%
Related
Conditions, medicines and genes
Other TPMT SNPs
- rs1142345C;Cpossibly incapable of detoxifying certain drugsImportant
- rs1800460T;Tincapable of detoxifying byproducts of certain drugsImportant
- rs1800462G;Gincapable of detoxifying certain drugsImportant
- rs56161402T;TTPMT*8 homozygote; likely issues detoxifying certain drugsWorth knowing
- rs2842951C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs1800584 is a rare SNP in the TPMT gene, potentially encoding a variant incapable of detoxifying byproducts of certain antineoplastic and immunosuppressant drugs. In general, individuals must have two nonfunctioning TPMT alleles for the toxicity to be pronounced. The rs1800584(A) SNP defines the TPMT*4A allele (OMIM). wikipedia thiopurine drugs metabolized by TPMT include azathioprine, mercaptopurine, and thioguanine
Source and license
Adapted from rs1800584 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.