rs2842951
A SNP in the TPMT gene on chromosome 6. Its most notable genotype is C;C: common in complete genomics
- Gene
- TPMT
- Location
- Chr 618,135,452 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 44%
- European ancestry (Utah)C;C 62%
- Han Chinese (Beijing)C;C 69%
- Japanese (Tokyo)C;C 58%
- Yoruba (Nigeria)C;C 11%
- African ancestry (Southwest US)C;C 21%
- Chinese (Denver)C;C 70%
- Gujarati IndianC;C 52%
- Luhya (Kenya)C;C 14%
- Mexican ancestry (Los Angeles)C;C 66%
- Maasai (Kenya)C;C 9%
- TuscanC;C 51%
Related
Other TPMT SNPs
- rs1142345C;Cpossibly incapable of detoxifying certain drugsImportant
- rs1800460T;Tincapable of detoxifying byproducts of certain drugsImportant
- rs1800462G;Gincapable of detoxifying certain drugsImportant
- rs1800584T;TTPMT*4A homozygote; likely issues detoxifying certain drugsImportant
- rs56161402T;TTPMT*8 homozygote; likely issues detoxifying certain drugsWorth knowing
Source and license
Adapted from rs2842951 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.