rs1800587

rs1800587, also known as C-889T, is a SNP in the IL-1 alpha IL1A gene. A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1800587(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. rs1800587 increases susceptibility to Intervertebral disc disease 1.31 times for (C;T) heterozygotes and 7.87 times for (T;T) homozygotes This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one . Gene-environment interaction effects on the development of immune responses in the 1st year of life. Association study of functional genetic variants of innate immunity related genes in celiac disease. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome. The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures. Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis]. Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. A candidate gene association study of 77 polymorphisms in migraine. Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study. The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians. Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes. Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease. Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.

A;A

This genotype has been linked to a 1.8cm increase in waist circumference as well as a 7.87x greater likelihood of developing Intervertebral disc disease (back problems such as bulging or herniated discs) - compared to those carrying the more common C allele.