rs1800587(A;A)

Increased waist circumference and a much greater risk of Intervertebral disc disease

Magnitude
2.3Worth knowing
Repute
Bad
Frequency
8%Average of 11 populations
On SNPedia
rs1800587(T;T)Minus strand
Gene
IL1A

Frequency

Share of people with A;A in each HapMap population.

  • Yoruba (Nigeria)20%
  • Maasai (Kenya)17%
  • Luhya (Kenya)12%
  • Gujarati Indian9%
  • Tuscan9%
  • European ancestry (Utah)7%
  • African ancestry (Southwest US)5%
  • Mexican ancestry (Los Angeles)5%
  • Japanese (Tokyo)2%
  • Han Chinese (Beijing)0%
  • Chinese (Denver)0%

Other genotypes of rs1800587

  1. G;GGoodnormalTypical · 0.056% of people
  2. A;GBadSlightly higher risk for lumbar disc diseaseMinor · 1.836% of people

All about rs1800587

Notes

From SNPedia

This genotype has been linked to a 1.8cm increase in waist circumference as well as a 7.87x greater likelihood of developing Intervertebral disc disease (back problems such as bulging or herniated discs) - compared to those carrying the more common C allele.

Source and license

Adapted from rs1800587(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.