rs1800858
A SNP in the RET gene on chromosome 10. Its most notable genotype is A;A: normal
- Gene
- RET
- Location
- Chr 1043,100,520 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 28%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratednormal
- A;GNot ratedprobably normal
- G;GNot ratedmay predispose somehow to Hirschsprung disease
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 9% A;G 32% G;G 59%
- European ancestry (Utah)A;A 4% A;G 49% G;G 48%
- Han Chinese (Beijing)A;A 29% A;G 49% G;G 23%
- Japanese (Tokyo)A;A 20% A;G 50% G;G 30%
- Yoruba (Nigeria)A;A 0% A;G 4% G;G 96%
- African ancestry (Southwest US)A;A 0% A;G 12% G;G 88%
- Chinese (Denver)A;A 21% A;G 51% G;G 28%
- Gujarati IndianA;A 10% A;G 46% G;G 45%
- Luhya (Kenya)A;A 0% A;G 7% G;G 93%
- Mexican ancestry (Los Angeles)A;A 5% A;G 21% G;G 74%
- Maasai (Kenya)A;A 5% A;G 31% G;G 64%
- TuscanA;A 7% A;G 34% G;G 59%
Related
Other RET SNPs
- rs74799832C;TMultiple Endocrine Neoplasia IIAVery important
- rs77316810A;TMultiple Endocrine Neoplasia IIAVery important
- rs77503355A;GMultiple Endocrine Neoplasia IIAVery important
- rs77558292C;TMultiple Endocrine Neoplasia IIAVery important
- rs77709286C;GMultiple Endocrine Neoplasia IIAVery important
- rs78935588C;GMultiple Endocrine Neoplasia IIAVery important
- rs79658334C;GMultiple Endocrine Neoplasia IIAVery important
- rs79781594A;GMultiple Endocrine Neoplasia IIAVery important
Source and license
Adapted from rs1800858 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.