rs1800860

A SNP in the RET gene on chromosome 10. Its most notable genotype is G;G: Normal sized kidneys as newborns

Gene
RET
Location
Chr 1043,111,239 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABad10% smaller kidneys as newbornsTypical · 0.06% of people
  2. A;GNot rated10% smaller kidneys as newbornsTypical · 0.028% of people
  3. G;GMost notableGoodNormal sized kidneys as newbornsMinor · 1.066% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 6% A;G 28% G;G 66%
  • European ancestry (Utah)A;A 4% A;G 48% G;G 48%
  • Han Chinese (Beijing)A;A 3% A;G 26% G;G 71%
  • Japanese (Tokyo)A;A 4% A;G 26% G;G 70%
  • Yoruba (Nigeria)A;A 0% A;G 19% G;G 81%
  • African ancestry (Southwest US)A;A 2% A;G 11% G;G 88%
  • Chinese (Denver)A;A 6% A;G 25% G;G 69%
  • Gujarati IndianA;A 8% A;G 43% G;G 50%
  • Luhya (Kenya)A;A 0% A;G 13% G;G 87%
  • Mexican ancestry (Los Angeles)A;A 31% A;G 40% G;G 29%
  • Maasai (Kenya)A;A 1% A;G 22% G;G 77%
  • TuscanA;A 6% A;G 33% G;G 61%

Other RET SNPs

All RET SNPs

Notes

From SNPedia

Notes

rs1800860 is a SNP in the RET ret proto-oncogene. A study of newborns concluded that Caucasian newborns who were clinically normal and carried a rs1800860(A) allele had kidney volumes 10% smaller and cord blood cystatin C levels 9% higher than those with the rs1800860(G;G) genotype. Since individuals with lower nephron numbers have an increased lifetime risk for essential hypertension or renal insufficiency, this may have clinical consequences in adult life (but this remains to be proven).

Source and license

Adapted from rs1800860 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.