rs1801157

A SNP in the CXCL12 gene on chromosome 10. Its most notable genotype is T;T: 1.4x higher risk for breast cancer

Gene
CXCL12
Location
Chr 1044,372,809 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.4x higher risk for breast cancerMinor · 1.45% of people
  2. C;TBad1.4x higher risk for breast cancerMinor · 1.427% of people
  3. C;CNot ratedNo summary available.Typical · 0.068% of people

SNPedia records rs1801157 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 5% C;T 27% C;C 68%
  • European ancestry (Utah)T;T 4% C;T 35% C;C 62%
  • Han Chinese (Beijing)T;T 10% C;T 31% C;C 59%
  • Japanese (Tokyo)T;T 9% C;T 40% C;C 51%
  • Yoruba (Nigeria)T;T 0% C;T 4% C;C 96%
  • African ancestry (Southwest US)T;T 0% C;T 16% C;C 84%
  • Chinese (Denver)T;T 9% C;T 39% C;C 51%
  • Gujarati IndianT;T 10% C;T 46% C;C 45%
  • Luhya (Kenya)T;T 0% C;T 13% C;C 87%
  • Mexican ancestry (Los Angeles)T;T 2% C;T 29% C;C 69%
  • Maasai (Kenya)T;T 1% C;T 13% C;C 86%
  • TuscanT;T 9% C;T 35% C;C 56%

Conditions, medicines and genes

Other CXCL12 SNPs

All CXCL12 SNPs

Notes

From SNPedia

Notes

rs1801157, also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 CXCL12 gene. rs1801157(A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). HIV-1/AIDS A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the rs1801157(A) allele was associated with higher risk for breast cancer, with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).

Source and license

Adapted from rs1801157 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.