rs180177098
A SNP in the PALB2 gene on chromosome 16. Its most notable genotype is TCT;TCT: Fanconi anemia, complementation group N
- Gene
- PALB2
- Location
- Chr 1623,635,495 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- AA;AAGoodcommon in clinvar
- AA;TCTBadincreased risk of breast cancer
- TCT;TCTMost notableBadFanconi anemia, complementation group N
On SNPedia: (AA;AA), (AA;TCT), (TCT;TCT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PALB2 SNPs
- rs118203997T;TFanconi anemia, complementation group NVery important
- rs118203998C;CFanconi anemia, complementation group NVery important
- rs118203999A;AFanconi anemia, complementation group NVery important
- rs180177083A;AFanconi anemia, complementation group NVery important
- rs180177084-;-Fanconi anemia, complementation group NVery important
- rs180177085-;-Fanconi anemia, complementation group NVery important
- rs180177090-;-Fanconi anemia, complementation group NVery important
- rs180177091A;AFanconi anemia, complementation group NVery important
Notes
From SNPedia
Notes
AA;TCT
Rare mutation in the PALB2 gene, raising risk for breast cancer. See discussion at PALB2 gene.
TCT;TCT
see discussion at PALB2
Source and license
Adapted from rs180177098 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.