rs180177132

A SNP in the PALB2 gene on chromosome 16. Its most notable genotype is T;T: Fanconi anemia, complementation group N

Gene
PALB2
Location
Chr 1623,621,362 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadFanconi anemia, complementation group NVery important · 7.0
  2. C;TBad4x increased risk of breast cancerVery important · 4.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs180177132 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other PALB2 SNPs

All PALB2 SNPs

Notes

From SNPedia

Notes

rs180177132, also known as c.3113G>A or p.Trp1038*, represents a very rare mutation in the PALB2 gene on chromosome 16. A 2016 publication study involving 42,000 breast cancer cases concluded that rs180177132(A) carriers had an odds ratio of 4.2 (CI:1.8-9.6; p=6.9×10e-8) and a 95% (CI: 44-99%) chance of developing the disease by age 70.

T;T

see discussion at PALB2

C;T

Rare mutation in the PALB2 gene, raising risk for breast cancer. See discussion at rs180177132 and at PALB2.

Source and license

Adapted from rs180177132 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.