rs1804197

A SNP in the APC gene on chromosome 5. Its most notable genotype is A;A: Increased risk of familial colorectal cancer and Asperger's syndrome

Gene
APC
Location
Chr 5112,844,212 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIncreased risk of familial colorectal cancer and Asperger's syndromeWorth knowing · 2.0
  2. A;CBadIncreased risk of familial colorectal cancer and Asperger's syndromeMinor · 1.0
  3. C;CGoodcommon in complete genomicsTypical · 0.0

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other APC SNPs

All APC SNPs

Notes

From SNPedia

Notes

rs1804197, a SNP in the adenomatous polyposis of the colon APC gene, is associated with autism . Although many SNPs have been found in this gene in association with (successful) hunts for mutations predisposing individuals to colon cancers, this previously unidentified SNP is located in the 3' untranslated portion of the gene. Also in conjunction with a common four-SNP haplotype (TGAG for rs2229992, rs42427, rs459552, and rs465899), this SNP is reported to be associated with Asperger's sydrome in the Swedish population studied.

Source and license

Adapted from rs1804197 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.