rs1867277

A SNP in the FOXE1 gene on chromosome 9. Its most notable genotype is A;A: 2x increased risk for thyroid cancer

Gene
FOXE1
Location
Chr 997,853,632 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x increased risk for thyroid cancerWorth knowing · 2.0
  2. A;GBad1.5x increased risk for thyroid cancerMinor · 1.5
  3. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1867277, also known as -283G>A, is a SNP upstream of the FOXE1 gene. Based on ~1,000 thyroid cancer patients (and an equal number of controls), a per allele odds ratio of 1.49 (CI: 1.30-1.70, p=5.9x10e-9) was found for the rs1867277(A) allele. This allele is thought to be a causal variant.

Source and license

Adapted from rs1867277 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.