rs193922702
A SNP in the FGF23 gene on chromosome 12. Its most notable genotype is C;T: Autosomal dominant hypophosphatemic rickets (predicted)
- Gene
- FGF23
- Location
- Chr 124,370,563 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs193922702 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other FGF23 SNPs
- rs28937882A;GAutosomal dominant hypophosphatemic rickets (predicted)Very important
- rs104894347C;TAutosomal dominant hypophosphatemic rickets (predicted)Very important
- rs193922701C;GAutosomal dominant hypophosphatemic rickets (predicted)Very important
- rs104894342C;TCarrier of a tumoral calcinosis mutationImportant
- rs104894343A;GCarrier of a tumoral calcinosis mutationImportant
- rs104894344A;GCarrier of a tumoral calcinosis mutationImportant
- rs863224872C;TCarrier of a tumoral calcinosis mutationImportant
- rs1220533001C;GCarrier of a tumoral calcinosis mutationImportant
Notes
From SNPedia
Notes
aka c.536G>A (p.Arg179Gln or R179Q) Distribution of coronary blood flow in the left ventricular wall of dogs evaluated by the uptake of Xe-133. FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. Physiological regulation of renal sodium-dependent phosphate cotransporters. Fibroblast growth factor 23 reduces expression of type IIa Na+/Pi co-transporter by signaling through a receptor functionally distinct from the known FGFRs in opossum kidney cells. BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
C;T
Treatable condition; see text and links via main rs-page
Source and license
Adapted from rs193922702 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.