rs198358

A SNP in the NPPA-AS1 gene on chromosome 1. Its most notable genotype is T;T: normal

Gene
NPPA-AS1
Location
Chr 111,844,019 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratednormalTypical · 0.055% of people
  2. C;TGoodlower blood pressureTypical · 0.035% of people
  3. C;CGoodlower blood pressureTypical · 0.011% of people

SNPedia records rs198358 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 55% C;T 35% C;C 11%
  • European ancestry (Utah)T;T 53% C;T 41% C;C 6%
  • Han Chinese (Beijing)T;T 84% C;T 14% C;C 2%
  • Japanese (Tokyo)T;T 76% C;T 23% C;C <1%
  • Yoruba (Nigeria)T;T 20% C;T 50% C;C 31%
  • African ancestry (Southwest US)T;T 23% C;T 56% C;C 21%
  • Chinese (Denver)T;T 79% C;T 19% C;C 2%
  • Gujarati IndianT;T 55% C;T 39% C;C 7%
  • Luhya (Kenya)T;T 31% C;T 52% C;C 17%
  • Mexican ancestry (Los Angeles)T;T 79% C;T 16% C;C 5%
  • Maasai (Kenya)T;T 30% C;T 48% C;C 22%
  • TuscanT;T 73% C;T 26% C;C 2%

Conditions, medicines and genes

Other NPPA-AS1 SNPs

All NPPA-AS1 SNPs

Notes

From SNPedia

Show notes, about 160 words

A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower blood pressure and hypertension were associated with SNPs rs17376328(A), rs5068, rs198358(C), rs632793(G) 23andMe blog Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Dissecting complex traits: recent advances in hypertension genomics. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study. Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.

Source and license

Adapted from rs198358 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.