rs199473487
A SNP in the LOC107986861 gene on chromosome 7. Its most notable genotype is G;T: Romano-Ward Long QT Syndrome
- Gene
- LOC107986861
- Location
- Chr 7150,974,920 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- G;TMost notableBadRomano-Ward Long QT Syndrome
SNPedia records rs199473487 on the minus strand: (A;A), (A;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LOC107986861 SNPs
- rs121912511G;TRomano-Ward Long QT SyndromeVery important
- rs199472844A;GRomano-Ward Long QT SyndromeVery important
- rs199472855C;TRomano-Ward Long QT SyndromeVery important
- rs199472856C;TRomano-Ward Long QT SyndromeVery important
- rs199473413C;TRomano-Ward Long QT SyndromeVery important
- rs199473420C;GRomano-Ward Long QT SyndromeVery important
- rs199473421A;GRomano-Ward Long QT SyndromeVery important
- rs796052196A;TRomano-Ward Long QT SyndromeVery important
Notes
From SNPedia
Notes
rs199473487, also known as c.98A>C, p.Asn33Thr or N33T, represents a rare mutation in the KCNH2 gene on chromosome 7. Acting generally in an autosomal dominant manner, the rs199473487(C) allele is considered pathogenic for Long QT syndrome type 2 (LQT2). 23andMe name: i5012355 Note: 23andMe appears to have stopped releasing data for i5012355 as of their v5 chip
Source and license
Adapted from rs199473487 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.