rs199673455

A SNP in the GPD1 gene on chromosome 12. Its most notable genotype is C;C: hypertriglyceridemia

Gene
GPD1
Location
Chr 1250,107,640 (GRCh38)
Highest magnitude
6.4Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadhypertriglyceridemiaVery important · 6.4
  2. C;GBadCarrier of a pathogenic mutation for hypertriglyceridemiaImportant · 3.0
  3. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

GPD1 gene, c.686G>C (p.Arg229Pro) The minor allele is reported by one source in ClinVar to be pathogenic for a transient (infantile) form of hypertriglyceridemia, normally a recessively inherited condition.

C;C

see discussion

C;G

Unaffected unless carrying another pathogenic mutation in the GPD1 gene

Source and license

Adapted from rs199673455 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.