rs199692405

A SNP in the CARD11 gene on chromosome 7. Its most notable genotype is A;T: severe eczema possible

Gene
CARD11
Location
Chr 72,947,624 (GRCh38)
Highest magnitude
4.9Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;TMost notableBadsevere eczema possibleVery important · 4.9
  2. G;TBadsevere eczema possibleVery important · 4.9
  3. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (A;T), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs199692405 is a SNP in the CARD11 gene on chromosome 7. The c.171A>G variant is a synonymous variant of no known importance. The A>T and A>C are (in cDNA orientation, not dbSNP orientation) mutations leading to a dominant, mutant protein known as p.Glu57Asp (E57D), which is reported to be pathogenic for an atopic dermatitis, otherwise known as severe eczema.

A;T

see rs199692405 and CARD11

G;T

see rs199692405 and CARD11

Source and license

Adapted from rs199692405 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.