rs199718602
A SNP in the ADGRE2 gene on chromosome 19. Its most notable genotype is C;T: Vibratory urticaria (allergic reaction to vibrations)
- Gene
- ADGRE2
- Location
- Chr 1914,755,069 (GRCh38)
- Highest magnitude
- 3.3Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadVibratory urticaria (allergic reaction to vibrations)
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
rs199718602, also known as c.1475G>A, p.Cys492Tyr or C492Y, represents a very rare mutation in the ADGRE2 gene on chromosome 19. Based on several Lebanese families and functional studies, the rs199718602(T) allele, as oriented in dbSNP orientation, is considered pathogenic (causative) for an autosomally dominant form of vibratory urticaria, a disorder in which localized hives develop in response to excessive vibration.
C;T
see discussion at rs199718602
Source and license
Adapted from rs199718602 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.