rs2066702
A SNP in the ADH1B gene on chromosome 4. Its most notable genotype is G;G: common
- Gene
- ADH1B
- Location
- Chr 499,307,860 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 5%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2066702 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageG;G 84% A;G 15% A;A 2%
- European ancestry (Utah)G;G 100% A;G 0% A;A 0%
- Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
- Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
- Yoruba (Nigeria)G;G 51% A;G 41% A;A 8%
- African ancestry (Southwest US)G;G 61% A;G 33% A;A 5%
- Luhya (Kenya)G;G 72% A;G 28% A;A <1%
- Mexican ancestry (Los Angeles)G;G 93% A;G 7% A;A 0%
- Maasai (Kenya)G;G 92% A;G 8% A;A 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
This paper found significant association with rs2066702, the SNP that defines ADH1B*3, in African American families. Association was strongest with the ICD-10 definitions of alcoholism, with P=0.046 for PDTsum and 0.029 for PDTaverage; it was also significant for DSM-IV for PDTaverage (P=0.039). The high-risk allele was the C that encodes ADH1B*1, and the low-risk allele encodes ADH1B*3. A review of the (at times conflicting) findings regarding ADH1B genotypes and maternal and fetal alcohol syndromes is available.cdc.gov In some African American and Native American populations, the ADH1B*3 allele (Arg369Cys in exon 9) is correlated with protection against alcoholism.
G;G
one paper reports increased risk of alcoholism for African-Americans with this genotype.
Source and license
Adapted from rs2066702 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.