rs6413413
A SNP in the ADH1B gene on chromosome 4. Its most notable genotype is A;A: common in complete genomics
- Gene
- ADH1B
- Location
- Chr 499,318,127 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other ADH1B SNPs
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 120 words
rs6413413, also known as Thr60Ser, is a SNP in the alcohol dehydrogenase 1B ADH1B gene. The rs6413413(A) allele is the more common, encoding the amino acid threonine (Thr); the quite rare rs6413413(T) allele encodes the variant serine (Ser). On it's own, this SNP is said to explain 2.5% of the variability in the rate at which alcohol is metabolized, based on a study of 250 Spaniards. More significantly (in a statistical sense), this study concluded that combinations of this SNP and others were shown to affect alcohol metabolism; most of these combinations are represented by the gs211 genoset. Note that the effects of alcohol are higher in individuals who break down (basically, detoxify) ethanol more slowly.
Source and license
Adapted from rs6413413 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.