rs2156921

A SNP in the BCR gene on chromosome 22. Its most notable genotype is A;G: 1.29x increased risk for depression

Gene
BCR
Location
Chr 2223,226,876 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormal risk for depressionMinor · 1.045% of people
  2. A;GMost notableBad1.29x increased risk for depressionWorth knowing · 2.043% of people
  3. G;GBad1.29x increased risk for depressionWorth knowing · 2.011% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 45% A;G 43% G;G 11%
  • European ancestry (Utah)A;A 30% A;G 56% G;G 14%
  • Han Chinese (Beijing)A;A 56% A;G 36% G;G 8%
  • Japanese (Tokyo)A;A 46% A;G 41% G;G 13%
  • Yoruba (Nigeria)A;A 64% A;G 34% G;G 3%
  • African ancestry (Southwest US)A;A 47% A;G 39% G;G 14%
  • Chinese (Denver)A;A 49% A;G 42% G;G 9%
  • Gujarati IndianA;A 34% A;G 47% G;G 20%
  • Luhya (Kenya)A;A 66% A;G 28% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 45% A;G 48% G;G 7%
  • Maasai (Kenya)A;A 34% A;G 53% G;G 14%
  • TuscanA;A 28% A;G 55% G;G 18%

Conditions, medicines and genes

Other BCR SNPs

All BCR SNPs

Notes

From SNPedia

Notes

rs2156921, a SNP in the BCR gene on chromosome 22, has been associated with increased risk for depression. The odds ratio for carriers of the minor allele (G) are reported as 1.29 (p=0.031) based on a study of 329 Japanese patients.

Source and license

Adapted from rs2156921 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.