rs2171492

A SNP in the CPA4 gene on chromosome 7. Its most notable genotype is T;T: Higher prostate cancer risk

Gene
CPA4
Location
Chr 7130,310,900 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. T;TMost notableBadHigher prostate cancer riskWorth knowing · 2.011% of people

On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 11%
  • European ancestry (Utah)T;T 8%
  • Han Chinese (Beijing)T;T 17%
  • Japanese (Tokyo)T;T 11%
  • Yoruba (Nigeria)T;T <1%
  • African ancestry (Southwest US)T;T 16%
  • Chinese (Denver)T;T 15%
  • Gujarati IndianT;T 10%
  • Luhya (Kenya)T;T 7%
  • Mexican ancestry (Los Angeles)T;T 10%
  • Maasai (Kenya)T;T 6%
  • TuscanT;T 22%

Conditions, medicines and genes

Notes

From SNPedia

Notes

(rs2171492, Cys303Gly) in CPA4 was associated with an increased risk of aggressive prostate cancer among younger ...

T;T

Results: The nonsynonymous coding SNP (rs2171492, Cys303Gly) in CPA4 was associated with an increased risk of aggressive prostate cancer among younger patients (<66 years). Specifically, men carrying the TT genotype had an approximately two-fold increased risk for being diagnosed with intermediate-to-high risk disease (Odds Ratio=1.83, p=0.04). In the overall population (all ages) none of the CPA4 SNPs demonstrated a statistically significant association with prostate cancer.

References

Source and license

Adapted from rs2171492 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.