rs2171492(T;T)

Higher prostate cancer risk

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
11%Average of 11 populations
On SNPedia
rs2171492(T;T)
Gene
CPA4

Frequency

Share of people with T;T in each HapMap population.

  • Tuscan22%
  • Han Chinese (Beijing)17%
  • African ancestry (Southwest US)16%
  • Chinese (Denver)15%
  • Japanese (Tokyo)11%
  • Mexican ancestry (Los Angeles)10%
  • Gujarati Indian10%
  • European ancestry (Utah)8%
  • Luhya (Kenya)7%
  • Maasai (Kenya)6%
  • Yoruba (Nigeria)<1%

Other genotypes of rs2171492

    All about rs2171492

    Notes

    From SNPedia

    Results: The nonsynonymous coding SNP (rs2171492, Cys303Gly) in CPA4 was associated with an increased risk of aggressive prostate cancer among younger patients (<66 years). Specifically, men carrying the TT genotype had an approximately two-fold increased risk for being diagnosed with intermediate-to-high risk disease (Odds Ratio=1.83, p=0.04). In the overall population (all ages) none of the CPA4 SNPs demonstrated a statistically significant association with prostate cancer.

    References

    Source and license

    Adapted from rs2171492(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

    SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.