rs2227589

A SNP in the SERPINC1 gene on chromosome 1. Its most notable genotype is C;C.

Gene
SERPINC1
Location
Chr 1173,917,078 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.077% of people

SNPedia records rs2227589 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 77%
  • European ancestry (Utah)C;C 81%
  • Han Chinese (Beijing)C;C 53%
  • Japanese (Tokyo)C;C 64%
  • Yoruba (Nigeria)C;C 88%
  • African ancestry (Southwest US)C;C 93%
  • Chinese (Denver)C;C 40%
  • Gujarati IndianC;C 79%
  • Luhya (Kenya)C;C 94%
  • Mexican ancestry (Los Angeles)C;C 95%
  • Maasai (Kenya)C;C 88%
  • TuscanC;C 75%

Conditions, medicines and genes

Other SERPINC1 SNPs

All SERPINC1 SNPs

Notes

From SNPedia

Notes

Gene variants associated with deep vein thrombosis. Updated analysis of gene variants associated with deep vein thrombosis. rs2227589 in SERPINC1 (risk allele frequency, 0.10) OR 1.29 (95% CI, 1.10-1.49) associated with plasma anti-FXa activity and antithrombin levels: carriers of the A allele had slightly but significantly lower anticoagulant activity and levels than GG subjects (97.0+/-7.3% vs. 94.6+/-8.4%; p=0.032; 99.5+/-5.8% vs. 94.8+/-5.6%; p=0.001; respectively)

Source and license

Adapted from rs2227589 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.