rs2227692

A SNP in the SERPINE1 gene on chromosome 7. Its most notable genotype is C;T: 1.6x higher risk for diffuse gastric cancer

Gene
SERPINE1
Location
Chr 7101,135,963 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.062% of people
  2. C;TMost notableBad1.6x higher risk for diffuse gastric cancerMinor · 1.634% of people
  3. T;TBad1.6x higher risk for diffuse gastric cancerMinor · 1.64% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 62% C;T 34% T;T 4%
  • European ancestry (Utah)C;C 86% C;T 14% T;T 0%
  • Han Chinese (Beijing)C;C 47% C;T 47% T;T 7%
  • Japanese (Tokyo)C;C 42% C;T 53% T;T 4%
  • Yoruba (Nigeria)C;C 74% C;T 22% T;T 3%

Conditions, medicines and genes

Other SERPINE1 SNPs

All SERPINE1 SNPs

Notes

From SNPedia

Notes

rs2227692, also known as c.1162+162C>T, is a SNP in the SERPINE1 gene. A study of 612 Korean patients with gastric cancer concluded that the rs2227692 C/T and T/T genotypes had 1.6x greater risk for diffuse gastric cancer than the C/C genotype (p = .00084).

C;T

see discussion at rs2227692

T;T

see discussion at rs2227692

Source and license

Adapted from rs2227692 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.