rs6092
A SNP in the SERPINE1 gene on chromosome 7. Its most notable genotype is G;G: common on affy axiom data
- Gene
- SERPINE1
- Location
- Chr 7101,128,436 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 7%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 82%
- European ancestry (Utah)G;G 79%
- Han Chinese (Beijing)G;G 67%
- Japanese (Tokyo)G;G 82%
- Yoruba (Nigeria)G;G 100%
Related
Notes
From SNPedia
Show notes, about 150 words
Plasminogen-activator inhibitor-1 polymorphisms are associated with obesity and fat distribution in the Quebec Family Study: evidence of interactions with menopause. Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study. 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia. A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder. Contribution of genetic and metabolic syndrome to omental adipose tissue PAI-1 gene mRNA and plasma levels in obesity.
Source and license
Adapted from rs6092 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.