rs2227902
A SNP in the REST gene on chromosome 4. Its most notable genotype is G;G: common in complete genomics
- Gene
- REST
- Location
- Chr 456,930,934 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 8%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 86%
- European ancestry (Utah)G;G 88%
- Han Chinese (Beijing)G;G 88%
- Japanese (Tokyo)G;G 84%
- Yoruba (Nigeria)G;G 86%
- African ancestry (Southwest US)G;G 86%
- Chinese (Denver)G;G 91%
- Gujarati IndianG;G 93%
- Luhya (Kenya)G;G 78%
- Mexican ancestry (Los Angeles)G;G 91%
- Maasai (Kenya)G;G 80%
- TuscanG;G 85%
Related
Notes
From SNPedia
Show notes, about 120 words
- rs2227902 and rs3796530 were found to be in 100% LD with a variable number tandem repeat (VNTR) length variant in the REST gene in a sample of 746 elderly Caucasians. Minor alleles (T and A, respectively) at both locations associated with the 4-length VNTR, while common alleles associated with the VNTR 5-length repeat. Carriers of the 4-length VNTR homozygous for the Val66 variant in the BDNF gene performed slightly, but significantly (p = 0.004), better than those without in the general cognitive tests performed in the study. Carriers of the 5-length VNTR and the 66Met BDNF variant had significantly lower g (p = 0.01), but the effect was not as great as the individual effect of the 66Met allele.
Source and license
Adapted from rs2227902 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.